《Organocatalyst in Direct C(sp2)-H Arylation of Unactivated Arenes: [1-(2-Hydroxyethyl)-piperazine]-Catalyzed Inter-/Intra-molecular C-H Bond Activation》 was published in Journal of Organic Chemistry in 2020. These research results belong to Yadav, Lalit; Tiwari, Mohit K.; Shyamlal, Bharti Rajesh Kumar; Chaudhary, Sandeep. Application of 529-28-2 The article mentions the following:
In the presence of 10 mol% 1-piperazineethanol, aryl iodides and bromides underwent arylation with benzene mediated by KOt-Bu to yield biaryls. N-Aryl 2-bromobenzamides underwent cyclization mediated by KOt-Bu in the presence of 40 mol% 1-piperazineethanol and 40 mol% 4-dimethylaminopyridine in mesitylene to yield phenanthridinones. Study of the reaction mechanism using kinetics and kinetic isotope effects and inhibition studies are consistent with the formation of aryl radical anions and a single electron transfer mechanism. After reading the article, we found that the author used 1-Iodo-2-methoxybenzene(cas: 529-28-2Application of 529-28-2)
1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Application of 529-28-2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem