Xia, Yingchun; Song, Ziyuan; Tan, Zhengzhong; Xue, Tianrui; Wei, Shiqi; Zhu, Lingyang; Yang, Yingfeng; Fu, Hailin; Jiang, Yunjiang; Lin, Yao; Lu, Yanbing; Ferguson, Andrew L.; Cheng, Jianjun published an article in 2021. The article was titled 《Accelerated polymerization of N-carboxyanhydrides catalyzed by crown ether》, and you may find the article in Nature Communications.Application In Synthesis of 1,4,7,10,13-Pentaoxacyclopentadecane The information in the text is summarized as follows:
The recent advances in accelerated polymerization of N-carboxyanhydrides (NCAs) enriched the toolbox to prepare well-defined polypeptide materials. Herein we report the use of crown ether (CE) to catalyze the polymerization of NCA initiated by conventional primary amine initiators in solvents with low polarity and low hydrogen-bonding ability. The cyclic structure of the CE played a crucial role in the catalysis, with 18-crown-6 enabling the fastest polymerization kinetics. The fast polymerization kinetics outpaced common side reactions, enabling the preparation of well-defined polypeptides using an α-helical macroinitiator. Exptl. results as well as the simulation methods suggested that CE changed the binding geometry between NCA and propagating amino chain-end, which promoted the mol. interactions and lowered the activation energy for ring-opening reactions of NCAs. This work not only provides an efficient strategy to prepare well-defined polypeptides with functionalized C-termini, but also guides the design of catalysts for NCA polymerization The results came from multiple reactions, including the reaction of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Application In Synthesis of 1,4,7,10,13-Pentaoxacyclopentadecane)
1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Application In Synthesis of 1,4,7,10,13-Pentaoxacyclopentadecane
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem