Application In Synthesis of 1,2-DiphenyldisulfaneIn 2020 ,《Rhodium(III)-catalyzed carboxylate-directed ortho-selective thiolation of benzoic acids》 was published in Organic Chemistry Frontiers. The article was written by Wang, Dongjie; Zhou, Kehan; Zhang, Jingyu; Zhao, Yingsheng. The article contains the following contents:
A regioselective rhodium-catalyzed carboxylate-directed thiolation process was developed. Several benzoic-acid derivatives 2-R-3-R1-4-R2-5-R3-C6HC(O)OH (R = H, Me, Et, OMe, Ph, Cl, OPh; R1 = H, Me, Cl, OMe, OEt; R2 = H, Me, OMe, OEt, OBn, pentyl; R3 = H, Me) and disulfides R4SSR4 (R4 = propan-2-yl, cyclohexyl, Ph, etc.) were found to be well-tolerated, and they yielded the corresponding products 2-R-3-R1-4-R2-5-R3-6-S(R4)-C6C(O)OH in moderate to good yields. Compounds such as the key precursor of roflumilast can be obtained via this reaction, thereby highlighting the potential of this synthetic approach. In the experimental materials used by the author, we found 1,2-Diphenyldisulfane(cas: 882-33-7Application In Synthesis of 1,2-Diphenyldisulfane)
1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Application In Synthesis of 1,2-DiphenyldisulfaneAlthough ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem