In 2019,ACS Chemical Biology included an article by Takashima, Ippei; Kusamori, Kosuke; Hakariya, Hayase; Takashima, Megumi; Vu, Thi Hue; Mizukami, Yuya; Noda, Naotaka; Takayama, Yukiya; Katsuda, Yousuke; Sato, Shin-ichi; Takakura, Yoshinobu; Nishikawa, Makiya; Uesugi, Motonari. COA of Formula: C9H19NO4. The article was titled 《Multifunctionalization of Cells with a Self-Assembling Molecule to Enhance Cell Engraftment》. The information in the text is summarized as follows:
Cell-based therapy is a promising approach to restoring lost functions to compromised organs. However, the issue of inefficient cell engraftment remains to be resolved. Herein, we take a chem. approach to facilitate cell engraftment by using self-assembling mols. which modify two cellular traits: cell survival and invasiveness. In this system, the self-assembling mol. induces syndecan-4 clusters on the cellular surface, leading to enhanced cell viability. Further integration with Halo-tag technol. provided this self-assembly structure with matrix metalloproteinase-2 to functionalize cells with cell-invasion activity. In vivo experiments showed that the pretreated cells were able to survive injection and then penetrate and engraft into the host tissue, demonstrating that the system enhances cell engraftment. Therefore, cell-surface modification via an alliance between self-assembling mols. and ligation technologies may prove to be a promising method for cell engraftment. In addition to this study using tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate, there are many other studies that have used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6COA of Formula: C9H19NO4) was used in this study.
tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.COA of Formula: C9H19NO4
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem