In 2019,Organic Chemistry Frontiers included an article by Song, Zehua; Wang, Guotong; Li, Wei; Li, Shengkun. Recommanded Product: m-Methoxyphenol. The article was titled 《Innate pharmacophore assisted selective C-H functionalization to therapeutically important nicotinamides》. The information in the text is summarized as follows:
The application of the pre-validated pharmacophore 2-(2-oxazolinyl)anilines (R)/(S)-I (R = H, Me, Et, benzyl) as an innate directing group in the C-H etherification and amination of nicotinamides II for the efficient synthesis of drug- and agrochem.-like mols. was determined An operationally simple, and regioselective C-H functionalization of nicotinamides (R)/(S)-II was first accomplished using a complicated variation of copper salts. All the specific procedures used were easy to utilize, without external oxidants or ligands. The feasibility is highlighted using an alternative synthesis of diflufenican with a rapid synthesis of niacin related pharmaceuticals or analogs III (R1 = H, 3-CH3OC6H4O, 2-methoxy-4-(prop-2-en-1-yl)phenyl, 4-methylpiperidin-1-yl, etc.; R2 = H, 2-methoxy-4-(prop-2-en-1-yl)phenyl, 3-methylpiperidin-1-yl, etc.). In the experiment, the researchers used many compounds, for example, m-Methoxyphenol(cas: 150-19-6Recommanded Product: m-Methoxyphenol)
m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneRecommanded Product: m-Methoxyphenol
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem