In 2019,Organic & Biomolecular Chemistry included an article by Shaifali; Ram, Shankar; Thakur, Vandna; Das, Pralay. Formula: C7H7IO. The article was titled 《Synthesis of α,β-alkynyl ketones via the nickel catalyzed carbonylative Sonogashira reaction using oxalic acid as a sustainable C1 source》. The information in the text is summarized as follows:
An efficient and economic nickel-dppb catalyzed-carbonylative Sonogashira cross-coupling reaction was demonstrated to provide rapid access to various α,β-alkynyl ketones RC(O)C≡CR1 [R = Ph, 4-MeC6H4, 4-BrC6H4, etc.; R1 = Ph, 2-ClC6H4, 4-MeOC6H4, etc.] from aryl iodides and terminal alkynes using oxalic acid as the ex-situ C1 source in a double vial (DV) system. Notably, the role of the ligand in combination with the Ni catalyst for the selective formation of carbonylative Sonogashira products was investigated and supported with control experiments In this process, for the first time, oxalic acid was used as an ex-situ solid, bench stable, easy to handle and efficient CO surrogate in a DV-system for the carbonylative Sonogashira coupling reaction with vast substrate scope. The results came from multiple reactions, including the reaction of 1-Iodo-2-methoxybenzene(cas: 529-28-2Formula: C7H7IO)
1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Formula: C7H7IO
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem