《Structural characterization of new zinc(II) complexes with N2O2 chelating thiosemicarbazidato ligands; investigation of the relationship between their DNA interaction and in vitro antiproliferative activity towards human cancer cells》 was published in New Journal of Chemistry in 2020. These research results belong to Kaya, Busra; Yilmaz, Zehra Kubra; Sahin, Onur; Aslim, Belma; Ulkuseven, Bahri. Computed Properties of C8H8O3 The article mentions the following:
Two new zinc(II) complexes were synthesized by condensation of 4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedione-S-methyl-thiosemicarbazone with salicylaldehyde or 4-methoxy-salicylaldehyde. Structures of the N2O2-chelate complexes, Zn1 and Zn2, were explicated by IR, 1H NMR, ESI-MS and X-ray crystallog. Electronic spectral anal. was performed to assign the nature of the interaction between the complexes and calf thymus DNA (CT-DNA). DNA cleavage activities of the complexes were investigated by gel electrophoresis (pBR322 DNA). The results indicated that the complexes bind to CT-DNA via an intercalation mode and the binding of Zn2 is stronger than that of Zn1. Relatively high concentrations of the zinc complexes were found to encourage the cleavage of DNA from supercoiled form (Form I) to nicked circular form (Form II). The antiproliferative activity of the complexes was determined against human colorectal adenocarcinoma (HT-29) and human cervical carcinoma (HeLa) cell lines by MTT assay. The tests revealed that the complex Zn2 exhibited a higher antiproliferative effect than Zn1 on HT-29 and HeLa cells, analogical to the data from DNA interaction experiments The studies demonstrated that complex Zn2 could be a good candidate as a chemotherapeutic drug targeting DNA. In the experiment, the researchers used 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Computed Properties of C8H8O3)
2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Computed Properties of C8H8O3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem