Name: 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acidIn 2019 ,《Will the polyphenol and adapalene combination be a good strategy on acne vulgaris?》 appeared in Medical Hypotheses. The author of the article were Janani, S. K.; Sureshkumar, Raman; Upadhyayula, Sai Surya Nikitha; Karthika, Chenmala; Vasanthi, C.. The article conveys some information:
Acne vulgaris is a common disease which affects about 85% of the population. Various topical drugs are available, but the retinoid derivatives are mostly taken into consideration. They are used as a first-line treatment drugs. However, they also have few side effects. Whereas, adapalene which is a third generation topical retinoid has fewer side effects compared to other derivatives In this, we hypothesize that the combination therapy of adapalene and flavonoid could improve the efficacy and thereby it can also decrease the treatment time. Since, flavonoids possess multiple activities we assume that it can improve the action of the drug by showing a synergistic activity. Moreover, when we incorporate these two drugs in nanoemulgel, it can easily penetrate into the skin and produce its therapeutic action. Hence, we assume that if this hypothesis proves to be correct then this method will be an effective one in treating acne (pustule). In the part of experimental materials, we found many familiar compounds, such as 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Name: 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid)
6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Name: 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid
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