Hirata, Shuichi; Osako, Takao; Uozumi, Yasuhiro published their research in Helvetica Chimica Acta in 2021. The article was titled 《Palladium-Catalyzed Aminocarbonylation of Aryl Halides with N,N-Dialkylformamide Acetals》.Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal The article contains the following contents:
Herein, a protocol for the palladium-catalyzed aminocarbonylation of aryl halides using less-toxic formamide acetals as bench-stable aminocarbonyl sources under neutral conditions has been developed. Various aryl (including heteroaryl) halides reacted with N,N-dialkylformamide acetals in the presence of a catalytic amount of tris(dibenzylideneacetone)dipalladium(0)-chloroform adduct and xantphos to give the corresponding aromatic carboxamides at 90-140°C without any activating agents or bases in up to quant. chem. yield. This protocol was applied to aryl bromides, aryl iodides and a triflate, as well as to relatively less-reactive aryl chlorides. A wide range of functionalities on the aromatic ring of the substrates was tolerated under the aminocarbonylation conditions. The catalytic aminocarbonylation was used to prepare the insect repellent N,N-diethyl-3-methylbenzamide as well as a synthetic intermediate of the dihydrofolate reductase inhibitor triazinate. The experimental process involved the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal)
N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal
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