In 2022,Gu, Jia; Xiao, Pan-Lei; Wang, Jie; Zhong, Liang; Nie, Xu-Liang; Peng, Da-Yong published an article in Journal of Molecular Structure. The title of the article was 《Synthesis, crystal structure, spectroscopic characterization and anti-fungal activity of Ethyl 2-Oxo-2H-chromene-3-carboxylate Derivatives》.Quality Control of m-Methoxyphenol The author mentioned the following in the article:
A series of Et 2-oxo-2H-chromene-3-carboxylate derivatives I [R1 = H, CH3, Br, etc.; R2 = H, OCH3] was synthesized by the ester cyclization of di-Et malonate and salicylaldehydes which was obtained from corresponding phenols. The single crystal of compounds I [R1 = OCF3, OCH3; R2 = H] were obtained and characterized by X-ray. Compound I [R1 = OCF3; R2 = H] crystallized in the triclinic system with space group P-1 and compound I [R1 = OCH3; R2 = H] crystallized in the monoclinic system with space group P21/c. The potential anti-fungal activities of the synthesized compounds was studied against five kinds of common fungi at concentrations of 200 ppm and 500 ppm and results showed that the target compounds exhibited certain anti-fungal activity against tested strains. The inhibition rate of compound I [R1 = CH3; R2 = H] was the highest against Fusarium oxysporum, up to 60.29% at 500 ppm. Compound I [R1 = CH3; R2 = H] was promising to become the lead compound of pesticide in the future. In the experiment, the researchers used m-Methoxyphenol(cas: 150-19-6Quality Control of m-Methoxyphenol)
m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneQuality Control of m-Methoxyphenol
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem