Category: ethers-buliding-blocksIn 2020 ,《Synthesis of 4,4-Disubstituted 1,2-Thiazinane-5-one 1,1-Dioxides via the CSIC[#] Reaction Strategy》 was published in ChemistrySelect. The article was written by Dyachenko, Maksim S.; Kochetkov, Artem O.; Dobrydnev, Alexey V.; Milokhov, Demyd S.; Shishkina, Svitlana V.; Konovalova, Irina S.; Omelchenko, Irina V.; Volovenko, Yulian M.. The article contains the following contents:
A series of sp3-enriched 2,2-disubstituted 1,2-thiazinane-5-one 1,1-dioxides (including spirocyclic derivatives) I (R1 = R2 = Me, Et, -(CH2)4-, -(CH2)5-, etc.), II (R1 = R2 = Me; R3 = NH2, Me, phenyl) and III (R1 = R2 = Me) has been synthesized through the CSIC [Carbanion mediated Sulfonate (Sulfonamido) Intramol. Cyclization] reaction strategy. In particular, 2,2-disubstituted alkyl 3-aminopropanoates C(R1)(R2)(CO2R4)CH2NH3+Cl- (R4 = Me, Et) were subsequently sulfonylated with mesyl chloride followed by alkylation with Me iodide to give the key precursor 2,2-disubstituted Me 3-(methylsulfonamido)propanoates C(R1)(R2)(CO2R4)CH2N(Me)SO2Me. The latter were treated with sodium hydride and underwent the intramol. sulfa-Dieckmann cyclization yielding the target 4,4-disubstituted 1,2-thiazinane-5-one 1,1-dioxides (so-called β-keto-δ-sultams) I. The structure of the target compounds was confirmed by an X-ray diffraction study. The results came from multiple reactions, including the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Category: ethers-buliding-blocks)
N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Category: ethers-buliding-blocks
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem