《Condensation of ninhydrin with phenols: Regioselective formation of diverse organic scaffolds and crystal structure studies》 was written by Das, Purak; Maity, Suvendu; Ghosh, Prasanta; Dutta, Arpita; Das, Suven. Name: m-Methoxyphenol And the article was included in Journal of Molecular Structure in 2020. The article conveys some information:
A range of phenolic compounds were reacted with ninhydrin in acid medium to afford different indanone-based mols. via regioselective C-C bond formation were studied. Ninhydrin reacts with 2,7-Dihydroxynaphthalene and 4-cyanophenol in AcOH producing ortho selective adducts in cyclic hemiketal structure and ring-opened diketo forms. On the other hand, ortho-substituted phenols like o-cresol, guaiacol, o-chloro/iodophenol condense with ninhydrin to accomplish para selective diarylated adducts, whereas 3-methoxy phenol provided corresponding monoarylated adduct as the major product. Different hydroxy benzoic acids delivered versatile scaffolds like diarylated indanone, indenofuran, benzofuran or spirolactone depending upon the substitution pattern and acidity of the reaction medium. All the compounds are characterized by 1H and 13C NMR spectra. In the solid state, scissors-shaped mol. diarylated adduct has been found to form inclusion complex with disordered o-cresol mol. and function as building unit of supramol. network. In the crystal structure of spirolactone, anti-parallel motif of dipolar···dipolar (C=O(δ-)···C(δ+) = O) interaction results ladder-like arrangement. In the experimental materials used by the author, we found m-Methoxyphenol(cas: 150-19-6Name: m-Methoxyphenol)
m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Name: m-Methoxyphenol
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