《Triptolide Directly Inhibits dCTP Pyrophosphatase》 was written by Corson, Timothy W.; Cavga, Hueseyin; Aberle, Nicholas; Crews, Craig M.. Computed Properties of C9H19NO4This research focused ontriptolide dCTP pyrophosphatase inhibitor biotinylated derivative preparation cytotoxicity. The article conveys some information:
Triptolide is a potent natural product, with documented antiproliferative, immunosuppressive, anti-inflammatory, antifertility, and antipolycystic kidney disease effects. Despite a wealth of knowledge about the biol. of this compound, direct intracellular target proteins have remained elusive. The authors synthesized a biotinylated photoaffinity derivative of triptolide, and used it to identify dCTP pyrophosphatase 1 (DCTPP1) as a triptolide-interacting protein. Free triptolide interacts directly with recombinant DCTPP1, and inhibits the enzymic activity of this protein. Triptolide is thus the first dCTP pyrophosphatase inhibitor identified, and DCTPP1 is a biophys. validated target of triptolide. In addition to this study using tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate, there are many other studies that have used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Computed Properties of C9H19NO4) was used in this study.
tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Computed Properties of C9H19NO4
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem