In 2022,Chaves-Carballo, Katherine; Lamoureux, Guy V.; Perez, Alice L.; Bella Cruz, Alexandre; Cechinel Filho, Valdir published an article in RSC Advances. The title of the article was 《Novel one-pot synthesis of a library of 2-aryloxy-1,4-naphthoquinone derivatives. Determination of antifungal and antibacterial activity》.Name: m-Methoxyphenol The author mentioned the following in the article:
The development of new antibiotics and inexpensive antifungals is an important field of research. Based on the privileged pharmacophore of lawsone, a series of phenolic ether derivatives of 1,4-naphthoquinone I (R = H, CH3, OCH3, etc.; R1 = H, NO2, Cl, etc.; R2 = H, OCH3, Br, etc.; R3 = H, Cl, CH3, etc.; R4 = H, Br, Cl, etc.) were synthesized easily in one step in reasonable yields. All the new compounds were characterized and tested as potential antifungal and antibacterial agents. Compound I (R1, R2, R4 = H; R3 = Cl; R = 2,4-Cl2C6H3O) has significant antibacterial action (as good as or better than the controls) against E. coli and S. aureus. Against C. albicans, compounds I (R1, R2, R3, R4 = H; R = Br), (R1, R2, R3, R4 = H; R = Cl), (R, R2, R3, R4 = H; R1 = Cl), (R, R2, R3, R4 = H; R1 = CH3) were the best candidates as antifungals. Using a qual. structure-activity anal., a correlation between molar mass and antimicrobial activity was identified, regardless of the substituent group on the phenolic moiety, except for I (R1, R2, R4 = H; R3 = Cl; R = 2,4-Cl2C6H3O) and (R1, R3, R4 = H; R, R2 = Cl) where electronic effects seem more important. An in silico evaluation of the absorption, distribution, metabolism and excretion (ADME) for I (R, R2, R3, R4 = H; R1 = NO2), (R1, R2, R3, R4 = H; R = NO2), (R1, R2, R4 = H; R3 = Cl; R = 2,4-Cl2C6H3O) and (R1, R3, R4 = H; R, R2 = Cl) was made, indicating that the classic Lipinski’s rule of five applies in all cases. In the experiment, the researchers used m-Methoxyphenol(cas: 150-19-6Name: m-Methoxyphenol)
m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneName: m-Methoxyphenol
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem