《Native amine-directed site-selective C(sp3)-H arylation of primary aliphatic amines with aryl iodides》 was published in Chinese Chemical Letters in 2020. These research results belong to Pramanick, Pranab K.; Zhou, Zhibing; Hou, Zhenlin; Ao, Yufei; Yao, Bo. Product Details of 529-28-2 The article mentions the following:
A simple and efficient method for site-selective C(sp3)-H arylation of primary aliphatic amines by aryl iodides were established. In the presence of only 5 mol% Pd(OAc)2, a wide range of aliphatic amines including O-benzyl and O-silyl amino alcs. were arylated at γ- or δ-positions by aryl iodides containing a broad scope of functional groups. The synthetic application of this method had also been demonstrated by large-scale synthesis, the synthesis of a fingolimod analog and the conjugation with natural D-menthol and fluorescent 1,8-naphthalimide. In the part of experimental materials, we found many familiar compounds, such as 1-Iodo-2-methoxybenzene(cas: 529-28-2Product Details of 529-28-2)
1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Product Details of 529-28-2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem