Miao, An-Qi; Zhou, Meng; Chen, Jing-Long; Wang, Shi-Chao; Hao, Wen-Juan; Tu, Shu-Jiang; Jiang, Bo published their research in Advanced Synthesis & Catalysis in 2021. The article was titled 《Pd-Catalyzed Asymmetric Addition of Arylboronic Acids to Pyrazolinone Ketimines》.Formula: C7H9BO3 The article contains the following contents:
An asym. addition of arylboronic acids to pyrazolinone ketimines was reported using palladium/chiral N,N’-disulfonyl bisimidazoline (Bim) catalytic system, producing 25 examples of enantioenriched 4-amino-5-pyrazolones I [R1 = Ph, 4-FC6H4, 4-MeOC6H4, etc.; R2 = t-Bu, Ph, p-tolyl, etc.; Ar = Ph, 3-MeOC6H4, 4-BrC6H4, etc.; stereo = R] bearing one quaternary carbon stereocenter with 60-91% yields and 81-98% ee. The reaction demonstrated remarkable compatibility regarding pyrazolinone ketimines and arylboronic acids, rendering an enantioselective access to chiral aza-heterocycles bearing α-tertiary amines. In addition to this study using 3-Methoxyphenylboronic acid, there are many other studies that have used 3-Methoxyphenylboronic acid(cas: 10365-98-7Formula: C7H9BO3) was used in this study.
3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Formula: C7H9BO3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem