Menard, Travis; Laverny, Aragorn; Denmark, Scott E. published their research in Journal of Organic Chemistry in 2021. The article was titled 《Synthesis of Enantioenriched 3,4-Disubstituted Chromans Through Lewis-Base Catalyzed Carbosulfenylation》.COA of Formula: C7H8O2 The article contains the following contents:
A method for the catalytic, enantioselective, carbosulfenylation of alkenes to construct 3,4-disubstituted chromans was described. Alkene activation proceeded through the intermediacy of enantioenriched, configurationally stable, thiiranium ions generated from catalytic Lewis-base activation of an electrophilic sulfenylating agent. The transformation affords difficult to generate enantioenriched 3,4-disubstituted chromans in moderate to high yields and excellent enantioselectivities. A variety of substituents are compatible including electronically diverse functional groups as well as several functional handles such as aryl halides, esters, anilines, and phenols. The resulting thioether moiety was amenable to a number of functional group manipulations and transformations. Notably, the pendant sulfide was successfully cleaved to furnish a free thiol which readily provides access to most sulfur-containing functional groups which are present in natural products and pharmaceuticals. The experimental part of the paper was very detailed, including the reaction process of m-Methoxyphenol(cas: 150-19-6COA of Formula: C7H8O2)
m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneCOA of Formula: C7H8O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem