《Synthesis and cytotoxicity of (-)-homo-renieramycin G and its derivatives》 was written by Ma, Yantao; Pan, Xuan; Guan, Baohe; Zhang, Guangyan; Liu, Zhanzhu. Electric Literature of C9H10O2 And the article was included in Organic & Biomolecular Chemistry in 2020. The article conveys some information:
(-)-Homo-renieramycin G (I) and its twenty derivatives were prepared from L-tyrosine Me ester via a multi-step route. Their cytotoxicities were tested against four human cancer cell lines (A549, HeLa, KB and BGC-823). (-)-Renieramycin G and (-)-homo-renieramycin G showed comparable cytotoxicity against these four cancer cell lines, which indicated that the expansion of ring C from the six-membered 1,4-piperazinone to the seven-membered 1,4-diazepanone had no obvious impact on the cytotoxicity. The compound with Me side chain and compounds with heterocyclic aromatic side chains at C-23 exhibited the most potent cytotoxicity with the IC50 values at the level of 10-6 M. In the experiment, the researchers used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Electric Literature of C9H10O2)
2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Electric Literature of C9H10O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem