In 2022,Li, Haiwei; Wang, Shouxin; Ma, Wenxiao; Cheng, Boyang; Yi, Yanliang; Ma, Xinyuan; Xiao, Sulong; Zhang, Lihe; Zhou, Demin published an article in Journal of Medicinal Chemistry. The title of the article was 《Discovery of Pentacyclic Triterpenoid PROTACs as a Class of Effective Hemagglutinin Protein Degraders》.Quality Control of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The author mentioned the following in the article:
Influenza hemagglutinin that drives viral entry into cells via the membrane fusion process is an up-and-coming antiviral drug target. Herein, we described for the first time the design, synthesis, and biol. characteristics of a new class of pentacyclic triterpenoid-based proteolysis targeting chimeras (PROTACs) to enhance the degradation of hemagglutinin target. Among these PROTACs, V3 (I) showed the best degradation effect on the hemagglutinin with a median degradation concentration of 1.44 μM in a ubiquitin and proteasome-dependent manner and broad-spectrum anti-influenza A virus activity but not affected the entry of influenza virus. Moreover, i.v. injection of V3 (I) protected mice against influenza A virus-induced toxic effects. Further diazirine-containing photo-crosslinking mass spectrometric anal. of hemagglutinin complexes indicated crosslinking to Asn15, Thr31, and Asn27, a novel target of hemagglutinin. Taken together, our data revealed that oleanolic acid-based PROTACs could degrade hemagglutinin protein, providing a new direction toward the discovery of potential anti-influenza drugs. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Quality Control of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)
tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Quality Control of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem