《Synthesis of some chalcone derivatives, in vitro and in silico toxicity evaluation》 was published in Rasayan Journal of Chemistry in 2020. These research results belong to Kristanti, A. N.; Suwito, H.; Aminah, N. S.; Haq, K. U.; Hardiyanti, H. D.; Anggraeni, H.; Faiza, N.; Anto, R. S.; Muharromah, S.. Electric Literature of C8H8O2 The article mentions the following:
The objevtives of this study was to synthesize some chalcone derivatives I [R = 4-F, 4-N(Me)2, 2-OMe, etc.] using conventional Claisen-Schmidt condensation by reacting 2-hydroxyacetophenone and some substituted benzaldehydes using NaOH 40%, followed by evaluating their cytotoxicity in vitro against HeLa cancer cells line using MTT method and analyzing mol. docking on p53 and MDM2 interaction. Cytotoxicity test exhibited that 2,5-dimethoxy-2′-hydroxychalcone and 4-chloro-2′-hydroxychalcone gave very low IC50, but both did not showed potential apoptosis activity, while in docking anal. 4-chloro-2′-hydroxychalcone showed the best results. In the experiment, the researchers used 2-Methoxybenzaldehyde(cas: 135-02-4Electric Literature of C8H8O2)
2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Electric Literature of C8H8O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem