Application In Synthesis of 2-(Benzyloxy)acetaldehydeIn 2021 ,《Construction of Enantioenriched 4,5,6,7-Tetrahydrofuro[2,3-b]pyridines through a Multicatalytic Sequence Merging Gold and Amine Catalysis》 was published in Advanced Synthesis & Catalysis. The article was written by Genet, Manon; Takfaoui, Abdelilah; Marrot, Jerome; Greck, Christine; Moreau, Xavier. The article contains the following contents:
A series of enantioenriched 4,5,6,7-tetrahydrofuro[2,3-b]pyridines I (R1 = Ph, 2-MeC6H4, 2-thienyl, etc.; R2 = Me, Pr, Bn, etc.; R3 = Ph, 4-MeOC6H4, 4-FC6H4, etc.) were accessed by a cycloisomerization/cycloaddition strategy. Starting from ynamide derivatives and aldehydes, yields ranging from 27 to 90% and high levels of stereoselectivity (de>95%, 93-99% ee) were obtained through sequential relay catalysis. The concurrent use of a gold complex with a diphenylprolinol silyl ether was applied to a combination of diversely functionalized substrates. The experimental process involved the reaction of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Application In Synthesis of 2-(Benzyloxy)acetaldehyde)
2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Application In Synthesis of 2-(Benzyloxy)acetaldehyde
Referemce:
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Ether | (C2H5)2O – PubChem