In 2016,Fabre, Benjamin; Picha, Jan; Vanek, Vaclav; Selicharova, Irena; Chrudinova, Martina; Collinsova, Michaela; Zakova, Lenka; Budesinsky, Milos; Jiracek, Jiri published 《Synthesis and evaluation of a library of trifunctional scaffold-derived compounds as modulators of the insulin receptor》.ACS Combinatorial Science published the findings.HPLC of Formula: 139115-91-6 The information in the text is summarized as follows:
We designed a combinatorial library of trifunctional scaffold-derived compounds, which were derivatized with 30 different inhouse-made azides. The compounds were proposed to mimic insulin receptor (IR)-binding epitopes in the insulin mol. and bind to and activate this receptor. This work has enabled us to test our synthetic and biol. methodol. and to prove its robustness and reliability for the solid-phase synthesis and testing of combinatorial libraries of the trifunctional scaffold-derived compounds Our effort resulted in the discovery of two compounds, which were able to weakly induce the autophosphorylation of IR and weakly bind to this receptor at a 0.1 mM concentration Despite these modest biol. results, which well document the well-known difficulty in modulating protein-protein interactions, this study represents a unique example of targeting the IR with a set of nonpeptide compounds that were specifically designed and synthesized for this purpose. We believe that this work can open new perspectives for the development of next-generation insulin mimetics based on the scaffold structure.tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6HPLC of Formula: 139115-91-6) was used in this study.
tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.HPLC of Formula: 139115-91-6
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem