The author of 《Mechanochemical Pd(II)-Catalyzed Direct and C-2-Selective Arylation of Indoles》 were Das, Dharmendra; Bhutia, Zigmee T.; Chatterjee, Amrita; Banerjee, Mainak. And the article was published in Journal of Organic Chemistry in 2019. Safety of 1-Iodo-2-methoxybenzene The author mentioned the following in the article:
A mechanochem. method for the preparation of synthetically useful 2-arylindoles is developed using Pd(II) as the catalyst in the absence of phosphine ligands in a ball-mill. The developed protocol is highly C-2 selective and tolerant of structural variations with electron-rich and electron-deficient substituents both in indoles and iodoarenes. Arylation is possible in both unprotected indoles and N-protected indoles with the electron-donating group with the former substrate being relatively slower to react and little less yielding. Indoles with a deactivated five-membered ring could also take part in the reaction with ease. The scalability of the reaction was demonstrated by conducting the reaction in the gram scale. In general, the reactions were achieved in a shorter time than the conventional methods. The experimental process involved the reaction of 1-Iodo-2-methoxybenzene(cas: 529-28-2Safety of 1-Iodo-2-methoxybenzene)
1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Safety of 1-Iodo-2-methoxybenzene
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem