In 2019,Angewandte Chemie, International Edition included an article by Ye, Fei; Berger, Florian; Jia, Hao; Ford, Joseph; Wortman, Alan; Boergel, Jonas; Genicot, Christophe; Ritter, Tobias. Recommanded Product: 2-Methoxybenzaldehyde. The article was titled 《Aryl Sulfonium Salts for Site-Selective Late-Stage Trifluoromethylation》. The information in the text is summarized as follows:
Incorporation of the CF3 group into arenes has found increasing importance in drug discovery. Herein, we report the first photoredox-catalyzed cross-coupling of aryl thianthrenium salts with a copper-based trifluoromethyl reagent, which enables a site-selective late-stage trifluoromethylation of arenes. The reaction proceeds with broad functional group tolerance, even for complex small mols. on gram scale. The method was further extended to produce pentafluoroethylated derivatives In the experiment, the researchers used 2-Methoxybenzaldehyde(cas: 135-02-4Recommanded Product: 2-Methoxybenzaldehyde)
2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Recommanded Product: 2-Methoxybenzaldehyde
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem