《Highly Selective Room-Temperature Suzuki-Miyaura Coupling of Bromo-2-sulfonyloxypyridines for Unsymmetrical Diarylpyridines》 was written by Jeon, Young-Kyo; Lee, Jae-Yeon; Kim, Seo-Eun; Kim, Won-Suk. Category: ethers-buliding-blocksThis research focused onunsym diarylpyridine chemoselective preparation Suzuki coupling bromosulfonyloxypyridine boronic acid. The article conveys some information:
A new and mild synthetic approach has been developed for the synthesis of pharmaceutically important unsym. diarylpyridines via chemoselective Suzuki-Miyaura coupling reactions of bromo-2-sulfonyloxypyridines. Most reactions allow for facile access to aryl-2-sulfonyloxypyridines at room temperature in yields of 5-99% with excellent chemoselectivity in the presence of Pd(OAc)2 (2.0 mol %) and Ad2BnP (2.4 mol %). The second arylation of the remaining tosyl or triflyl group in the monoarylpyridine derivatives obtained was successfully accomplished for the synthesis of unsym. 2,3-, 2,4-, 2,5-, and 2,6-diarylpyridine derivatives Furthermore, a one-pot synthesis of unsym. diarylpyridines starting from bromo-2-sulfonyloxypyridine was accomplished to demonstrate the practical convenience. Finally, with this method, an antibacterial agent, a topoisomerase inhibitor, and etoricoxib, a nonsteroidal anti-inflammatory drug, were successfully synthesized from the corresponding bromo-2-hydroxypyridines in overall yields of 80, 86, and 49%, resp. The experimental part of the paper was very detailed, including the reaction process of 3-Methoxyphenylboronic acid(cas: 10365-98-7Category: ethers-buliding-blocks)
3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Category: ethers-buliding-blocks
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