In 2022,Hu, Yijie; Wang, Xiaoli; Ren, Nan; Li, Na; Li, Jianyang; Chen, Jie; Zhang, Hui; Deng, Hongmei; Cao, Weiguo; Lin, Jin-Hong published an article in European Journal of Organic Chemistry. The title of the article was 《A Convenient Synthesis of Fluoroalkylated Benzimidazole- or Indole-fused Benzoxazines》.Reference of 2-Hydroxy-4-methoxybenzaldehyde The author mentioned the following in the article:
Herein, the first synthesis of fluoroalkylated benzimidazole- or indole-fused benzoxazines I (R = CF3, C2F5, C3H7; R1 = 2-OMe, 2-Br, 4-Cl, etc.) or II (R2 = H, F; R3 = H, 10-Me, 10-Br, 9,11-(Me)2) by using fluoroalkylated propiolates RCCC(O)2Me as building blocks is described. The reactions proceeded smoothly under mild conditions to give the desired products I and II in moderate to high yields. Notably, benzimidazole-fused products I were obtained by a convenient one-pot two-step process. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Reference of 2-Hydroxy-4-methoxybenzaldehyde)
2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Reference of 2-Hydroxy-4-methoxybenzaldehyde
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem