《Synthesis of 3-alkylideneisoindolin-1-ones via Sonogashira cyclocarbonylative reactions of 2-ethynylbenzamides》 was published in Journal of Organic Chemistry in 2020. These research results belong to Albano, Gianluigi; Giuntini, Stefano; Aronica, Laura Antonella. Quality Control of 1-Iodo-2-methoxybenzene The article mentions the following:
Cyclocarbonylative Sonogashira reactions of ortho-ethynylbenzamides were investigated. The process was carried out under CO pressure, in the presence of a very small amount of PdCl2(PPh3)2 (0.4 mol %) as a catalytic precursor, and without the need for a Cu salt as co-catalyst. 2-Ethynylbenzamide reacted successfully with iodoarenes bearing electron-withdrawing and electron-donating groups giving rise to different classes of compounds depending on the solvent used. On the contrary, N-(4-chlorophenyl)-2-ethynylbenzamide afforded exclusively polyfunctionalized isoindolinones I [R = H, 4-ClC6H4; Ar = Ph, 2-MeOC6H4, 4-MeOC6H4, 4-ClC6H4, 4-CNC6H4] with high stereoselectivity towards (E) isomers. In the experimental materials used by the author, we found 1-Iodo-2-methoxybenzene(cas: 529-28-2Quality Control of 1-Iodo-2-methoxybenzene)
1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Quality Control of 1-Iodo-2-methoxybenzene
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