In 2019,Journal of Medicinal Chemistry included an article by Yokoyama, Takeshi; Mizuguchi, Mineyuki. Electric Literature of C10H20O5. The article was titled 《Crown Ethers as Transthyretin Amyloidogenesis Inhibitors》. The information in the text is summarized as follows:
Transthyretin (TTR) is a tetrameric protein found in human serum and associated with amyloid diseases. Because the tetramer dissociation and misfolding of the monomer precede amyloid fibril formation, development of a small mol. that binds to TTR and stabilizes the TTR tetramer is an efficient strategy for the treatment of amyloidosis. Here, we report our discovery of the anti-TTR amyloidogenesis activities of crown ethers. X-ray crystallog. anal., binding assay, and chem. crosslinking assay showed that 4′-carboxybenzo-18C6 (4) stabilized the TTR tetramer by binding to the allosteric sites on the mol. surface of the TTR tetramer. In addition, 4 synergistically increased the stabilization activity of diflunisal, one of the most potent TTR amyloidogenesis inhibitors. These exptl. evidences establish that 4 is a valuable template compound as an allosteric inhibitor of TTR amyloidogenesis. The results came from multiple reactions, including the reaction of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Electric Literature of C10H20O5)
1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Electric Literature of C10H20O5
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem