In 2018,Spaeth, Andreas; Graeler, Andre; Maisch, Tim; Plaetzer, Kristjan published 《CureCuma-cationic curcuminoids with improved properties and enhanced antimicrobial photodynamic activity》.European Journal of Medicinal Chemistry published the findings.Related Products of 139115-91-6 The information in the text is summarized as follows:
The naturally occurring photosensitizer curcumin has excellent biocompatibility, but its antimicrobial photodynamic efficacy is limited by (i) weak adherence to Gram(-) cell walls, (ii) low (photo-)stability and (iii) limited solubility in water. In this study novel curcuminoids bearing cationic substituents were prepared by different synthetic routes. The derivatives exhibit excellent water solubility, improved photostability and low aggregation. All novel curcuminoids showed antibacterial photodynamic effects (>3 log10 reduction of CFU) against Escherichia coli and Staphylococcus aureus upon blue light illumination. In contrast to natural curcumin, effective photokilling of E. coli was possible without the addition of permeabilizing agents. Ten micromolar of the most active compound achieved a 7 log10 decrease of E. coli after light activation with a fluence of 33.8 J/cm2, whereas S. aureus was inactivated by more than 4 log10 at a fluence of 5.3 J/cm2. Overall the reduction in bacterial count was at least 100-fold more effective with these new curcuminoids in comparison to natural curcumin. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Related Products of 139115-91-6)
tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Related Products of 139115-91-6 They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem