Related Products of 60656-87-3In 2021 ,《Copper(I)-Catalyzed Asymmetric Conjugate 1,6-, 1,8-, and 1,10-Borylation》 appeared in Angewandte Chemie, International Edition. The author of the article were Shi, Chang-Yun; Eun, Jungmin; Newhouse, Timothy R.; Yin, Liang. The article conveys some information:
Catalytic asym. remote conjugate borylation is challenging as the control of regioselectivity is not trivial, the electrophilicity of remote sites is extenuated, and the remote asym. induction away from the carbonyl group is difficult. Herein, catalytic asym. conjugate 1,6-, 1,8- and 1,10-borylation was developed with excellent regioselectivity, which delivered α-chiral boronates in moderate to high yields with high enantioselectivity. The produced chiral boronate smoothly underwent oxidation, cross-coupling, and one-carbon homologation to give synthetically versatile chiral compounds in moderate yields with excellent stereoretention. Furthermore, a stereomechanistic anal. was conducted using DFT calculations, which provides insights into the origins of the regioselectivity. Finally, the present 1,6-borylation was successfully applied in an efficient one-pot asym. synthesis of (-)-7,8-dihydrokavain. In the experiment, the researchers used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Related Products of 60656-87-3)
2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Related Products of 60656-87-3
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Ether | (C2H5)2O – PubChem