Shang, Gao; Liu, Duan; Allen, Scott E.; Yang, Qin; Zhang, Xumu published the artcile< Asymmetric hydrogenation of α-primary and secondary amino ketones: efficient asymmetric syntheses of (-)-arbutamine and (-)-denopamine>, Product Details of C11H16O2, the main research area is asym hydrogenation amino ketone rhodium catalyst; alc amino chiral preparation rhodium catalyst.
Two β-receptor agonists (-)-denopamine (I) and (-)-arbutamine (II) were prepared in good yields and enantioselectivities by asym. hydrogenation of unprotected amino ketones for the first time by using Rh catalysts bearing electron-donating phosphine ligands. A series of α-primary and secondary amino ketones, e.g. ArCOCH2NHR (Ar = Ph, 2-MeOC6H4, 2-naphthyl, R = Me; Ar = Ph, R = Et), were synthesized and hydrogenated to produce various 1,2-amino alcs., e.g. ArCH(OH)CH2NHR, in good yields and with good enantioselectivities. This Rh electron-donating phosphine-catalyzed asym. hydrogenation rep- resents one of the most promising and convenient approaches towards the asym. synthesis of chiral amino alcs.
Chemistry – A European Journal published new progress about Amines, keto Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Product Details of C11H16O2.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem