In 2019,European Journal of Medicinal Chemistry included an article by Sang, Zhipei; Wang, Keren; Zhang, Pengfei; Shi, Jian; Liu, Wenmin; Tan, Zhenghuai. COA of Formula: C8H8O2. The article was titled 《Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer’s disease》. The information in the text is summarized as follows:
A series of novel chalcone derivatives I [n = 3,4,5,6; R1 = 3,4-dihydro-1H-isoquinolin-2-yl, (4-benzyl-1-piperidyl)] and II [n = 3,4,6; R2 = 4-fluoro, 2-methoxy, 4-dimethylamino] were synthesized and evaluated as multifunctional agents for the treatment of AD. Among of these synthesized compounds, compound I [n = 4, R1 = 3,4-dihydro-1H-isoquinolin-2-yl] was a selective BuChE inhibitor (IC50 = 2.6 μM) and selective MAO-B inhibitor (IC50 = 5.3 μM), which were supported by docking study. Compound compound I [n = 4, R1 = 3,4-dihydro-1H-isoquinolin-2-yl] also showed good antioxidant activity and was a selective metal chelator, as well as a neuroprotectant. Moreover, compound compound I [n = 4, R1 = 3,4-dihydro-1H-isoquinolin-2-yl] could significantly inhibit self-induced and Cu2+-induced Aβ1-42 aggregation with 70.2% and 80.7% inhibition rate, resp. and could disaggregate Cu2+-induced Aβ1-42 aggregation (73.5%), the further TEM images observed provided rational explanation. Besides, compound I [n = 4, R1 = 3,4-dihydro-1H-isoquinolin-2-yl] displayed good PAMPA-BBB permeability and conformed to the Lipinski’s rule of five. Further, compound I [n = 4, R1 = 3,4-dihydro-1H-isoquinolin-2-yl] presented precognitive effect on scopolamine-induced memory impairment in-vivo assay. Therefore, compound I [n = 4, R1 = 3,4-dihydro-1H-isoquinolin-2-yl] might be a promising multifunctional hit compound for the treatment of AD and the further structure optimization are in progress. In addition to this study using 2-Methoxybenzaldehyde, there are many other studies that have used 2-Methoxybenzaldehyde(cas: 135-02-4COA of Formula: C8H8O2) was used in this study.
2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.COA of Formula: C8H8O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem