《General Asymmetric Synthetic Strategy for the α-Alkylated 2,5,6-Trisubstituted Pyran of Indanomycin and Related Natural Products》 was published in European Journal of Organic Chemistry in 2020. These research results belong to Padma, Ravishetty; Srinivas, Beduru; Yadav, Jhillu S.; Mohapatra, Debendra K.. Application In Synthesis of 2-(Benzyloxy)acetaldehyde The article mentions the following:
A general synthetic strategy for convergent asym. synthesis of C1-C10 fragment I of tetraene-containing natural product indanomycin was achieved starting from 2-(benzyloxy)acetaldehyde which in turn was obtained from very inexpensive material cis-1,4-butene-diol. Key steps include Evans’ aldol reaction, HWE olefination, iodine-catalyzed tandem isomerization followed by C-O and C-C bond formation similar to our earlier report in constructing the trans-2,6-disubstituted dihydropyran ring and Evans’ asym. alkylation. In addition to this study using 2-(Benzyloxy)acetaldehyde, there are many other studies that have used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Application In Synthesis of 2-(Benzyloxy)acetaldehyde) was used in this study.
2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Application In Synthesis of 2-(Benzyloxy)acetaldehyde
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem