Computed Properties of C8H8O2In 2019 ,《Synthesis of New 6-[4-(2-Fluorophenylpiperazin-1-yl)]-3(2H)-Pyridazinone-2-Acetyl-2- (Substituted benzal)Hydrazone Derivatives and Evaluation of Their Cytotoxic Effects in Liver and Colon Cancer Cell Lines》 appeared in Pharmaceutical Chemistry Journal. The author of the article were Ozdemir, Zeynep; Basak-Turkmen, Nese; Ayhan, Idris; Ciftci, Osman; Uysal, Mehtap. The article conveys some information:
In this study, seven new 3(2H)-pyridazinone derivatives I (R = H, 2-Cl, 4-NMe2, 4-Me, 4-Cl, 4-Br, 2-MeO) expected to show cytotoxic activity in liver and colon cancer cell lines were synthesized. Compounds I were tested on HEP3B (liver cancer) and HTC116 (colon cancer) cell lines for cytotoxicity by using MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium] proliferation assay. Human fibroblast cells were used as a safety control in these tests. Compound I (R = 2-Cl) was the most active agent with respect to HEP3B and HTC116 cell lines. In the experiment, the researchers used 2-Methoxybenzaldehyde(cas: 135-02-4Computed Properties of C8H8O2)
2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Computed Properties of C8H8O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem