In 2022,Mohammed, Ehtesham U. R.; Porter, Zoe J.; Jennings, Ian G.; Al-Rawi, Jasim M. A.; Thompson, Philip E.; Angove, Michael J. published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Synthesis and biological evaluation of 4H-benzo[e][1,3]oxazin-4-ones analogues of TGX-221 as inhibitors of PI3Kβ》.Quality Control of m-Methoxyphenol The author mentioned the following in the article:
A novel series of TGX-221 analogs was prepared that include isosteric replacement of the 4H-pyrido[1,2-a]pyrimidin-4-one with a 4H-benzo[e][1,3]oxazin-4-one I (R = Ph, 3,5-F2C6H3, 3-ClC6H4, etc.; X = O, NH) scaffold. The compounds that included an -CH(CH3)NH- type linker showed comparable activity to TGX-221 analogs with the isosterism supported by the comparative SAR anal. The analogs containing an -CH(CH3)O- linker were less active but still showed useful SAR including a favored o-Me substitution. The experimental part of the paper was very detailed, including the reaction process of m-Methoxyphenol(cas: 150-19-6Quality Control of m-Methoxyphenol)
m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneQuality Control of m-Methoxyphenol
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem