Name: 2-(Benzyloxy)acetaldehydeIn 2019 ,《Asymmetric syn-1,3-Dioxane Construction via Kinetic Resolution of Secondary Alcohols Using Chiral Phosphoric Acid Catalysts》 was published in Asian Journal of Organic Chemistry. The article was written by Matsumoto, Akira; Asano, Keisuke; Matsubara, Seijiro. The article contains the following contents:
Herein, a novel enantioselective hemiacetalization/intramol. oxy-Michael addition cascade for the synthesis of syn-1,3-diol frameworks I [R = Ph, 2-naphthyl, PhCH=CH, etc.; OSi = OTBS, OTBPDS] via kinetic resolution of chiral secondary alcs. using chiral phosphoric acid catalysts was presented. By utilizing the recovered optically active starting material, both enantiomers of the corresponding protected 1,3-diols could be obtained with high optical purities. In addition, the products with a carbonyl group were converted diastereoselectively to longer optically active 1,3-polyols, which were representative motifs in polyketides. Moreover, the organocatalytic approach presented in this study facilitates a library construction of useful chiral building blocks for the asym. synthesis of bioactive compounds In the experiment, the researchers used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Name: 2-(Benzyloxy)acetaldehyde)
2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Name: 2-(Benzyloxy)acetaldehyde
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