Quality Control of 2-(Benzyloxy)acetaldehydeIn 2021 ,《Catalytic Regioselective Olefin Hydroarylation(alkenylation) by Sequential Carbonickelation-Hydride Transfer》 was published in Journal of the American Chemical Society. The article was written by Liu, Chen-Fei; Luo, Xiaohua; Wang, Hongyu; Koh, Ming Joo. The article contains the following contents:
Catalytic amounts of a dimeric Ni(I) complex and an exogenous alkoxide base promoted Markovnikov-selective hydroarylation(alkenylation) of unactivated and activated olefins using organo bromides or triflates derived from widely available phenols and ketones was reported for the synthesis of substituted alkanes. Products bearing aryl- and alkenyl-substituted tertiary and quaternary centers could be isolated in up to 95% yield and >99:1 regioisomeric ratios. Contrary to previous dual-catalytic methods that rely on metal-hydride atom transfer (MHAT) to the olefin prior to carbofunctionalization with a cocatalyst, mechanistic evidence points toward a nonradical reaction pathway that begins with site-selective carbonickelation across the C=C bond followed by hydride transfer using alkoxide as the hydride source. Utility of the single-catalyst protocol is highlighted through the synthesis of medicinally relevant scaffolds. In the experiment, the researchers used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Quality Control of 2-(Benzyloxy)acetaldehyde)
2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Quality Control of 2-(Benzyloxy)acetaldehyde
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