In 2022,Khaligh, Nader Ghaffari; Mihankhah, Taraneh published an article in Polycyclic Aromatic Compounds. The title of the article was 《Green and Solid-Phase Synthesis of New Dihydro-[1,2,4]Triazolo[1,5-a]Pyrimidine Scaffolds by Using Poly-Melamine-Formaldehyde as a Nitrogen-Rich Porous Organocatalyst》.Category: ethers-buliding-blocks The author mentioned the following in the article:
This work presented a new catalytic application of porous poly-melamine-formaldehyde (mPMF) for the efficient synthesis of dihydro-[1,2,4]triazolo[1,5-a]pyrimidines I [Ar = 2-MeOC6H4, 4-O2NC6H4, 2,4,6-tri-MeOC6H2, etc.]. According to the principles of green chem., the reaction was performed by planetary ball milling process at ambient and neat conditions. The heterogeneous catalyst could be reused up to five runs with no reducing of catalytic efficiency. A variety of dihydro-[1,2,4]triazolo[1,5-a]pyrimidines I were obtained in good to excellent yields under eco-friendly conditions. This work revealed that bifunctional porous organic polymers (POPs) containing base sites and acceptor-donner hydrogen bonding groups, as well as high porosity could play a vital role in the promotion of the one-pot multicomponent reactions in the solid phase. The main merits of current methodol. included short reaction time, wide substrate-scope and use of a metal-free heterogeneous organocatalyst, simple work-up process. The results came from multiple reactions, including the reaction of 2-Methoxybenzaldehyde(cas: 135-02-4Category: ethers-buliding-blocks)
2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Category: ethers-buliding-blocks
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem