Karale, Uttam B.; Shinde, Akash U.; Babar, Dattatraya A.; Sangu, Komal G.; Vagolu, Siva Krishna; Eruva, Vamshi K.; Jadav, Surender S.; Misra, Sunil; Dharmarajan, Sriram; Rode, Haridas B. published their research in Archiv der Pharmazie (Weinheim, Germany) in 2021. The article was titled 《3-Aryl-substituted imidazo[1,2-a]pyridines as antituberculosis agents》.Application In Synthesis of 1-Bromo-3-methoxybenzene The article contains the following contents:
3-Aryl-substituted imidazo[1,2-a]pyridines I [R1 = H, 6-Me, 7-Me, 8-Me; R2 = 4-tolyl, 2-naphthyl, 2-(4-methylanilino)-4-(trifluoromethyl)phenyl, etc.] were reported as potent antituberculosis agents. A small library of 3-aryl-substituted imidazo[1,2-a]pyridines I were synthesized using direct arylation followed by nitro reduction and finally Pd-catalyzed C-N coupling reactions. The compounds I thus obtained were evaluated against Mycobacterium tuberculosis H37Rv. Compound I [R1 = H, R2 = 3-cyanophenyl] was identified as an antituberculosis lead with a min. inhibitory concentration of 2.3μg/mL against M. tuberculosis H37Rv. This compound I [R1 = H, R2 = 3-cyanophenyl] showed a selectivity index of 35. The docking of compound I [R1 = H, R2 = 3-cyanophenyl] in the active site of the M. tuberculosis cytochrome bc1 complex cytochrome b subunit (Mtb QcrB) revealed key π-π interactions of I [R1 = H, R2 = 3-cyanophenyl] with the Tyr389 and Trp312 residues of Mtb QcrB. After reading the article, we found that the author used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Application In Synthesis of 1-Bromo-3-methoxybenzene)
1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Application In Synthesis of 1-Bromo-3-methoxybenzene
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