Quality Control of N,N-Dimethylformamide Dimethyl AcetalIn 2020 ,《Discovery of novel heat shock protein (Hsp90) inhibitors based on luminespib with potent antitumor activity》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Jung, Juyoung; Kwon, Jinsun; Hong, Soojung; Moon, An-Na; Jeong, Jinah; Kwon, Sungwook; Kim, Jeong-ah; Lee, Myoungjae; Lee, Hongsub; Lee, Jin Hee; Lee, Jeewoo. The article conveys some information:
A series of isosteric surrogates of the 4-Ph group in luminespib were investigated as new scaffolds of the Hsp90 inhibitor for the discovery of novel antitumor agents. Among the synthesized surrogates of isoxazole and pyrazole, compounds 4a, 5e and 12b exhibited potent Hsp90 inhibition in ATPase activity and Her2 degradation assays and significant antitumor activity in A2780 and HCT116 cell lines. Animal studies indicated that compared to luminespib, their activities were superior in A2780 or NCI-H1975 tumor xenograft models. A mol. modeling study demonstrated that compound 4a could fit nicely into the N-terminal ATP binding pocket. In the experiment, the researchers used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Quality Control of N,N-Dimethylformamide Dimethyl Acetal)
N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Quality Control of N,N-Dimethylformamide Dimethyl Acetal
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