The author of 《Access to Multifunctionalized Benzofurans by Aryl Nickelation of Alkynes: Efficient Synthesis of Anti-Arrhythmic Drug Amiodarone》 were Iqbal, Naeem; Iqbal, Naila; Maiti, Debabrata; Cho, Eun Jin. And the article was published in Angewandte Chemie, International Edition in 2019. Reference of 3-Methoxyphenylboronic acid The author mentioned the following in the article:
An unconventional nickel-catalyzed reaction was developed for the synthesis of multifunctionalized benzofurans from alkyne-tethered phenolic esters. The transformation involves the generation of a nucleophilic vinyl NiII species by the regioselective syn-aryl nickelation of an alkyne, which then undergoes an intramol. cyclization with phenol ester to yield highly functionalized 1,1-disubstituted alkenes with 3-benzofuranyl and (hetero)aryl substituents. The methodol. can be used for the late-stage benzofuran incorporation of various drug mols. and natural products, such as 2-propylvaleric acid, gemfibrozil, biotin, and lithocholic acid. Furthermore, this arylative cyclization method was successfully applied for the efficient synthesis of the anti-arrhythmic drug amiodarone. In the part of experimental materials, we found many familiar compounds, such as 3-Methoxyphenylboronic acid(cas: 10365-98-7Reference of 3-Methoxyphenylboronic acid)
3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Reference of 3-Methoxyphenylboronic acid
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem