《Green synthesis of 1H-pyrazolo[1,2-b]phthalazine-2-carbonitrile derivatives using a new bifunctional base-ionic liquid hybrid magnetic nanocatalyst》 was written by Hamidinasab, Mahdia; Bodaghifard, Mohammad Ali; Mobinikhaledi, Akbar. Synthetic Route of C8H8O2 And the article was included in Applied Organometallic Chemistry in 2020. The article conveys some information:
The ionic liquid-base N,N,2,2,6,6-hexamethyl-N-(3-(trimethoxysilyl)propyl)piperidin-4-ammonium iodide was grafted onto titana-coated NiFe2O4 nanoparticles for obtaining an efficient and reusable ionic liquid-base hybrid nanocatalyst. The structure of hybrid nanoparticles was characterized using FT-IR (Fourier-transform IR spectroscopy), field emission SEM, EDS (energy-dispersive X-ray spectroscopy), EDS map scan, Brunauer-Emmett-Teller surface area anal., CHN (elemental anal.), vibrating sample magnetometer and thermogravimetric anal. techniques. Furthermore, this novel hybrid catalyst was used in one-pot three-component synthesis of 3-amino-1-aryl-5,10-dioxo-1H-pyrazolo[1,2-b]phthalazine-2-carbonitrile derivatives I [R = H, 2-Cl, 4-NO2, etc.] under green and environmentally benign conditions. This protocol avoids the use of harmful catalysts, toxic solvents and harsh reaction conditions. The products were synthesized in excellent yields within short reaction time and identified using elemental anal., FT-IR, 1H NMR and 13C NMR spectroscopies. The results came from multiple reactions, including the reaction of 2-Methoxybenzaldehyde(cas: 135-02-4Synthetic Route of C8H8O2)
2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Synthetic Route of C8H8O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem