Gu, Weijie; Martinez, Sergio; Singh, Abhimanyu K.; Nguyen, Hoai; Rozenski, Jef; Schols, Dominique; Herdewijn, Piet; Das, Kalyan; De Jonghe, Steven published an article in 2021. The article was titled 《Exploring the dNTP -binding site of HIV-1 reverse transcriptase for inhibitor design》, and you may find the article in European Journal of Medicinal Chemistry.Recommanded Product: 60656-87-3 The information in the text is summarized as follows:
HIV-1 reverse transcriptase (RT) plays a central role in the viral life cycle, and roughly half of the FDA-approved anti-HIV drugs are targeting RT. Nucleoside analogs (NRTIs) require cellular phosphorylation for binding to RT, and to bypass this rate-limiting path, we designed a new series of acyclic nucleoside phosphonate analogs as nucleoside triphosphate mimics, aiming at the chelation of the catalytic Mg2+ ions via a phosphonate and/or a carboxylic acid group. Novel synthetic procedures were developed to access these nucleoside phosphonate analogs. X-ray structures in complex with HIV-1 RT/dsDNA demonstrated that their binding modes are distinct from that of our previously reported compound series. The impact of chain length, chirality and linker atom have been discussed. The detailed structural understanding of these new compounds provides opportunities for designing new class of HIV-1 RT inhibitors. After reading the article, we found that the author used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Recommanded Product: 60656-87-3)
2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Recommanded Product: 60656-87-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem