《Benzaldehyde and derivatives N(4)-phenyl-3-thiosemicarbazones: synthesis, characterization and biological activity》 was written by Glinma, Bienvenu; Medegan, Sedami; Yayi, Eleonore; Kpoviessi, Salome; Bero, Joanne; Quetin-Leclercq, Joelle; Poupaert, Jacques; Accrombessi, Georges; Gbaguidi, Fernand. SDS of cas: 135-02-4This research focused onthiosemicarbazone preparation antiparasitic activity. The article conveys some information:
A class of small mols., thiosemicarbazones and derivatives have been studied over the last few years due to their wide pharmacol. versatility. Due to having this wide-spectrum biol. activity, interest on these compounds has been considerably increased in the pharmaceutical sector at the present time. Here, benzaldehyde and derivatives were used on N(4)-phenyl-3-thiosemicarbazide with glacial acetic acid to synthesize four thiosemicarbazones corresponding (1-4) in good yields (64-85%). Structures of compounds were characterized by spectrometric alanal.: FT-IR, NMR 1H & 13C and MS spectra. A theor. study based on their chem. structure has been made. In vitro antiparasitic activity of products has been evaluated on the on the bloodstream form of the strain 427 of Trypanosoma bruceibrucei. All compounds presented phys. properties compatible with reasonable pharmacokinetics and drug availability, but they showed a low half inhibitory concentration (IC50> 100 μM) and then were not actives on the trypanosomes tested. Other biol. activity would be explored on other pathogens. The experimental part of the paper was very detailed, including the reaction process of 2-Methoxybenzaldehyde(cas: 135-02-4SDS of cas: 135-02-4)
2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.SDS of cas: 135-02-4
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