SDS of cas: 135-02-4In 2020 ,《Experimental and DFT mechanistic insights into one-pot synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones under catalysis of DBU-based ionic liquids》 appeared in New Journal of Chemistry. The author of the article were Fallah-Ghasemi Gildeh, Sara; Mehrdad, Morteza; Roohi, Hossein; Ghauri, Khatereh; Fallah-Ghasemi Gildeh, Sahar; Rad-Moghadam, Kurosh. The article conveys some information:
Benzylation of DBU followed by anion exchange of the resulting salt with trifluoroacetate gave nearly quant. ionic liq [Bn-DBU][TFA]. It is shown here to be an efficient catalyst for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones I (Ar = 4-nitrophenyl, 3-chlorophenyl, 2-methylphenyl, etc.; X = CN, COOEt) via the three-component reaction of phthalhydrazide, aromatic aldehydes ArCHO, and active α-methylene nitriles XCH2CN. DFT calculations at the B3LYP/SVP level and the exptl. results are in agreement with a three-step mechanism for this reaction. Based on the DFT calculations, the catalytic effect largely arises from the intrinsic ionic properties of the ionic liquid rather than its action as a simple base. These calculations also predict the existence of two close-in-energy activated complexes whose rate determining roles and energies depend on their interaction with the anionic component of the ionic liquid, as [Bn-DBU][TFA] has shown a higher catalytic activity than [Bn-DBU][OAc]. This mechanistic approach opens up new and promising insights into the rational design of ionic liquid catalysts for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones I. The synthetic method presented here has several prominent advantages. The experimental part of the paper was very detailed, including the reaction process of 2-Methoxybenzaldehyde(cas: 135-02-4SDS of cas: 135-02-4)
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Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem