In 2022,Bhat, Mashooq A.; Al-Omar, Mohamed A.; Naglah, Ahmed M.; Al-Dhfyan, Abdullah published an article in Polish Journal of Chemical Technology. The title of the article was 《Facile synthesis and anticancer activity of novel dihydropyrimidinone derivatives》.Application of 4637-24-5 The author mentioned the following in the article:
The enaminone, (2E)-3-(dimethylamino)-1-(3,4,5-trimethoxyphenyl) prop-2-en-1-one was prepared by refluxing 3,4,5-trimethoxy acetophenone with DMF dimethylacetal (DMF-DMA) without solvent for 12 h. The dihydropyrimidinone derivatives (1-9) were prepared by reacting enaminone, substituted benzaldehydes and urea in glacial acetic acid. The compounds (1-9) were synthesized in significant yield using one step multicomponent reaction. Structures of all the novel synthesized compounds were characterized and confirmed by various spectroscopic methods. The compounds were evaluated for their anti-cancer activity against HepG2 cancer cell line. Compound 9 displayed significant anti-cancer activity. During the apoptotic assay, it showed a significant increase in necrosis from 1.97% to 12.18% as compared to the control. Mechanism of anti-proliferation was performed by cell cycle distribution assay, which showed a decrease in G2+M from 12.90 to 8.13 as compared to control. The experimental process involved the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Application of 4637-24-5)
N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Application of 4637-24-5
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem