The author of 《A Bronsted Acid Catalyzed Cascade Reaction for the Conversion of Indoles to α-(3-Indolyl) Ketones by Using 2-Benzyloxy Aldehydes》 were Banerjee, Ankush; Maji, Modhu Sudan. And the article was published in Chemistry – A European Journal in 2019. HPLC of Formula: 60656-87-3 The author mentioned the following in the article:
A Bronsted acid catalyzed, operationally simple, scalable route to several functionalized α-(3-indolyl) ketones were developed and the long-standing regioisomeric issue was eliminated by choosing appropriate carbonyls. A readily available and cheap bottle reagent was used as the catalyst. This protocol was also applicable to the synthesis of densely functionalized α-(3-pyrrolyl) ketones. A detailed mechanistic study confirmed the involvement of enolether as a reaction intermediate. Several postsynthetic modifications along with easy access to β-carboline, tryptamines, tryptophols, and spiro-indolenine proclaim the synthetic utility of this powerful building block. On the basis of this concept, functionalized carbazoles were constructed by a cascade annulation strategy. In addition to this study using 2-(Benzyloxy)acetaldehyde, there are many other studies that have used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3HPLC of Formula: 60656-87-3) was used in this study.
2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).HPLC of Formula: 60656-87-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem