AlMarzouq, Douaa Salman published their research in European Journal of Chemistry in 2021. The article was titled 《Reactions under increased pressure: the reactivity of functionally substituted 3-oxo-2-arylhydrazones toward active methylene reagents in Q-tube》.Electric Literature of C5H13NO2 The article contains the following contents:
A one-pot two-component reaction of 3-oxo-2-arylhydrazones 4-XC6H4C(O)C(C(O)R)=NNH(4-R1C6H4) (X = H, Cl; R = H, OEt; R1 = H, Me) with active methylene nitriles such as malononitrile and benzoylacetonitrile under high pressure in a Q-tube safe reactor was reported. Comparison between conventional and Q-tube safe reactor-assisted synthesis of organic compounds was done by comparing total reaction time and percentage yield. The results show that the compound 5-cyano-6-oxo-1,4-diphenyl-1,6-dihydro-pyridazine-3-carboxylic acid Et ester was synthesized within 2 h in a yield of 97%. In addition, the pyrazolo[3,4-c]pyridines I were obtained in yields of 93 and 95% within 1 h reaction time, resp. The obtained results suggest that Q-tube safe reactor-assisted syntheses were led to higher product yields within very short reaction times.N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Electric Literature of C5H13NO2) was used in this study.
N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Electric Literature of C5H13NO2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem