In 2022,AL-Shammri, Khairiah Nasser; Elkanzi, Nadia A. A.; Arafa, Wael A. A.; Althobaiti, Ibrahim O.; Bakr, Rania B.; Moustafa, Shaima Mohamed Nabil published an article in Arabian Journal of Chemistry. The title of the article was 《Novel indan-1,3-dione derivatives: Design, green synthesis, effect against tomato damping-off disease caused by Fusarium oxysporum and in silico molecular docking study》.Category: ethers-buliding-blocks The author mentioned the following in the article:
An effective method for synthesizing series of twenty-two new compounds was performed starting from reaction of 1,2,3-indenetrione thiourea, and Et cyanoacetate under microwave irradiation and / or 2-(1,3-dioxo-1H-inden-2(3H)-ylidene) hydrazine carbothioamide with acetic anhydride. The designed new compounds have been successfully examined in-vitro for their antifungal activities. The relation between the structure of the synthesized compounds and their activity against tomato damping-off disease caused by Fusarium oxysporum fungi was studied and favorable results were obtained. The antifungal studies indicated that few compounds exerted the highest antifungal activities, while 7′-thioxo-7′,8′-dihydrospiro[indene-2,5′-pyrimido[4,5-d][1,3]oxazine]-1,3,4′(6’H)-trione and Et 6′-(4-hydroxybenzylideneamino)-1,3-dioxo-2′-thioxo-1,2′,3,3′-tetrahydro-1’H-spiro [indene-2,4′-pyrimidine]-5′-carboxylate recorded the lowest effect. The obtained results confirmed the possibility of the application of Et 6′-amino-1,3-dioxo-2′-thioxo-1,2′,3,3′-tetrahydro-1’H-spiro[indene-2,4′-pyrimidine]-5′-carboxylate as a new effective regulator of the vegetative growth of tomatoes. The mol. docking anal. was performed within succinate dehydrogenase (SDH) as a target enzyme in order to rationalize the promising findings obtained for the active compounds In the experiment, the researchers used many compounds, for example, 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Category: ethers-buliding-blocks)
2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Category: ethers-buliding-blocks
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem