《Ultrasound assisted eco-friendly synthesis of 3-cinnamoyl coumarins using N,N’-(1,2-phenylene)bis(2-aminobenzamide)dichloro cobalt immobilized on mesoporous Al-SBA-15 as a new and recyclable catalyst》 was published in Green Chemistry Letters and Reviews in 2020. These research results belong to Akbarzadeh, Zeinab; Safaei-Ghomi, Javad. Safety of 2-Hydroxy-4-methoxybenzaldehyde The article mentions the following:
A novel mesoporous Al-SBA-15 modified by N,N’-(1,2-phenylene)bis(2-aminobenzamide) dichloro cobalt has been prepared and applied as a reusable catalyst in the 3-cinnamoyl coumarins I (R = 4-Br, 2-OH, 4-F, etc.; R1 = H, 7-OMe, 6-OMe, 6-Br) synthesis via three-component reaction between benzaldehydes RC6H4CHO, salicylaldehydes like salicylaldehyde, 2-hydroxy-4-methoxybenzaldehyde, 2-hydroxy-5-methoxybenzaldehyde, 5-bromo-2-hydroxybenzaldehyde and Et acetoacetate by the assist of ultrasonic irradiation By using the nanocatalyst and also ultrasound irradiation, the facility and velocity of the above mentioned reaction were enhanced and an environment friendly condition was provided to synthesis of various 3-cinnamoyl coumarin compounds I. The properties and structure of nanocatalyst have been specified by methods including powder X-ray diffraction (XRD), energy dispersive spectroscopy (EDS), Fourier transform IR spectroscopy (FT-IR), transmission electron microscopy (TEM), nitrogen adsorption-desorption anal. and scanning electronic microscopy (SEM). Superiority of this novel and viable method is due to mild reaction condition, short reaction times, high yields of 3-cinnamoyl coumarins I, environmentally benign, recoverability of the CoCl2N,N’-(1,2-phenylene)bis (2-aminobenzamide)/Al-SBA-15 catalyst and reusability with important preservation in its catalytic activity. The experimental process involved the reaction of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Safety of 2-Hydroxy-4-methoxybenzaldehyde)
2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Safety of 2-Hydroxy-4-methoxybenzaldehyde
Referemce:
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Ether | (C2H5)2O – PubChem